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[Des-octanoyl]-Ghrelin, human

Name
[Des-octanoyl]-Ghrelin, human
Molecular structural formula
CAS Number
313951-59-6
Formula
C141H235N47O41
MW
3244.74
Sequence Shortening
GSSFLSPEHQRVQQRKESKKPPAKLQPR
Sequence
Gly-Ser-Ser-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg
InChIKey
BGHSOEHUOOAYMY-JTZMCQEISA-N
Purity
≥95%
References
[1].Ghrelin treatment protects lactotrophs from apoptosis in the pituitary of diabetic rats. Mol Cell Endocrinol . 2009 Jun 18 ; 309(1-2) 67
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Des-octanoyl (or Des-acyl) Ghrelin is the unacylated precursor peptide to Ghrelin. Des-octanoyl Ghrelin is converted to Ghrelin by the enzymic addition of an octanyl group. Studies indicate that the amount of Des-octanoyl Ghrelin in the circulation is approximately 20 fold higher than that of Ghrelin. Des-octanoyl Ghrelin is not an agonist of the Ghrelin growth hormone receptor 1a (GHSR1a).